In the following faq karl fischer titration, our experts are giving the answers to the most common questions concerning titration with mettler toledo compact titrators and karl fischer titration in general. In case of skin contact take off contaminated clothing and shoes immediately. Karl fischer titration is a titration method which uses volumetric or coulometric titration to determine the trace quantity of water in the sample. Karl fischer reagents for analytical techniques alfa aesar. The main composition of karl fischer reagent are 1. Karl fischer reagent laboratory chemicals article no. A stable end point high speed titration outstanding reproducibility. Toxicological information acute toxicity product information oral ld50 category 4.
The reagents include composit t5, composit t2 and composit t1, which di. Sodium tartrate, dihydrate, crystal, reagent, acs has a crystal structure that is able to capture a very precise amount of water and is used in the karl fischer moisture determination titration technique. Find karl fischer reagent dea list i chemical at now. Karl fischer titration is a classic titration method in chemical analysis that uses coulometric or. Water content by karl fischer the most important method of determination of water content is the karl fischer electrometric titration method. Volumetric karl fischer reagents come with a variety of options. Suitable for general purpose applications as well as for aldehydes and ketones. Karl fischer reagent is used in karl fischer titration to determine the water content in a sample. Water content determination by karl fischer learn all about karl fischer reagent its reaction and how to determine the water content by karl fischer. Karl fischer titration is the method of choice for water content determination. The use of trade names or commercial products are examples only, and any equivalent products may be substituted. Safety data sheet northwest missouri state university. However, the method depends on a kind of iodometry based on the reaction between the karl fischer reagent and water.
Check availability and compare product details karl fischer reagent solution a for pyridinebased volumetric karl fischer titration pyridine, sulfur dioxide, methanol, cas number. You can buy karl fischer reagent at ibuychemikals, the online chemical store which offers a wide range of chemicals for researchers, scholars, testing. Karl fischer titrators for water moisture determination. Karl fischer reagents hydranal composite 5, reagent for volumetric onecomponent karl fischer titration methanol free, honeywell fluka hydranal coulomat ag, reagent for coulometric kf titration anolyte solution, for cells with and without diaphragm, honeywell fluka. It is used to determine small amounts of water in a wide range of materials, including many polymerics. Karl fischer reagent, stabilized revision date 25apr2019 hazardous reactions none under normal processing.
With our range of aquastar reagents for volumetric water determination according to karl fischer method, you benefit from high titration rates and accurate, reliable results. It is based on a reagent which reacts with water and converts the water into a nonconductive chemical. In no event shall fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if fisher has been advised of the possibility of such damages. Volumetric karl fischer titration is recommended for determining water contents in samples with water levels of between 0. Some aspects of the determination of water by the karl fisher method. Karl fischer reagent definition is a colored solution of pyridine, sulfur dioxide, iodine, and anhydrous methanol that reacts quantitatively with water to form a colorless solution and is used to determine the amount of water in numerous substances. If you continue browsing the site, you agree to the use of cookies on this website. Check availability and compare product details karl fischer reagent solution b for pyridinebased volumetric karl fischer titration iodine, methanol, cas number. Karl fischer reagent, stabilized revision date 25apr2019 hazard statements flammable liquid and vapor harmful if swallowed harmful in contact with skin causes skin irritation causes serious eye irritation harmful if inhaled may damage fertility. The following reaction formula, in which pyridine is expressed as a. Volumetric reagents for water determination by the karl fischer. A colored solution of iodine, sulfur dioxide, and pyridine in methanol. Once you have your titration system you will need the appropriate reagents to perform your titration measurements. It is widely applied for moisture determination of drug substances because it is very rapid, specific and requires a very small amount of sample.
Karl fischer reagent definition of karl fischer reagent. Composition wavetrace composit is a line of onecomponent karl fischer reagents for volumetric determination of moisture. Looking back on half a century of experience in karl fischer titration, metrohm has shaped what coulometric and volumetric water analysis are today. The karl fischer titration is used in many different ways following its publication in 1935 and further applications are continually being explored. In products such as kerosene, transformer insulation oil or brake oil, the presence of unwanted moisture can have disastrous consequences. Aquastar combititrant aquastar combititrant reagents for onecomponent volumetric karl fischer analysis already contain all ingredients required by the karl fischer reaction iodine, base, and sulfur dioxide dissolved in. Karl fischer titration is an analytic system to determine the trace amount of water in solid, gases and liquids. Products marked with this symbol are discontinued sold till end of stock. Karl fischer reagents hydranal composite 5, reagent for volumetric onecomponent karl fischer titration methanol free, honeywell fluka hydranal water standard 1. Karl fischer reagent moisture estimation in food, pharmaceutical, chemicals and oil industries are estimated through karl fischer titration, kf reagent is used in analysis of water content in raw material, in process and finished products. It reacts quantitatively with water, becoming colorless.
Karl fischer reagent single solution pyridine free 1 ml of reagent 5 mg h2o approx. Karl fisher titration is a technique for the determination of moisture content. In the list of frequently asked questions you will find information pertaining to all areas of volumetric and coulometric karl fischer titration. By measuring the volume of the titer added, we can calculate the amount of water in the sample. Karl fischer reagent high purity laboratory chemicals. Karl fischer titration frequently asked questions metrohm. Aquastar reagents for volumetric karl fischer titration. Karl fischer reagent solution a honeywell research chemicals. Practical tips and hints on sample preparation and instrument operation. The solvent keeps flowing into the titration vessel after the addition, without the addition. The karl fischer method can be used with a wide range of substances. Karl fischer method uses the karl fischer reagents to determine the moisture content of a sample and it is a widely popular method because it allows you to determine the water content of drug in a very fast, accurate and specific way in addition to needing a very small amount of sample for the analysis. Composites 5,2,1 working with solvents is most popular but if youre looking for longer stability you may want to. Karl fisher provides for the specific detection of water content in a product.
Water determination using karl fischer titration water content needs to be determined at all stages of the manufacturing process from raw materials to finished goods. Central drug house p ltd 728 vardaan house new delhi2 india. Karl fischer reagents aquastar reagents, chemicals and. An essentially pyridinefree karl fischer reagent useful in the determination of water, comprises a dissolving agent containing sulfur dioxide and a pyridine substitute in a karl fischer solvent, and a titrating agent containing iodine in a karl fischer solvent, wherein the pyridine substitute is an alkali or alkaline earth metal benzoate or ammonia, and the reagent is essentially free of. Preparation of molar and normal solutions karl fischer reagent and its reactions determination of shelf life of solutions in. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Ankur choudhary print question forum 6 comments many official drugs contain varying amounts of water either in the form of water of crystallization i. Please allow extra time for your order to be processed. May damage the unborn child causes damage to organs. Karl fischer titration is an analytical technique to measure the amount of water contained in various samples, which may be solid, liquid or gaseous.
Alfa aesar is proud to introduce our line of karl fischer reagents. Water is determined by using commercially available standard karl fischer reagent integrated with a drying oven. Karl fischer reagent consists of iodine, sulfur dioxide, a base and a solvent, such as alcohol. Accurate and dependable results can be obtained to support work flow. Karl fischer reagent solution b honeywell research chemicals. Regulated item additional account information may be required. Show this safety data sheet to the doctor in attendance. Any wavetrace composit reagent contains all components required for a stoichiometric reaction of iodine with water in the sample. This faq karl fischer titration page will be expanded periodically. As shown in formula 1 below, the karl fischer method uses karl fischer reagent, which reacts quantitatively and selectively with water, to measure moisture content. Karl fischer reagents hydranal composite 5, reagent for volumetric onecomponent karl fischer titration methanol free, honeywell fluka hydranal water standard 10. The allnew omnis kf karl fischer titrator for volumetric water content determination offers a whole new level of. Us4416997a pyridinefree karl fischer reagent useful in.
The technique was developed by a chemist named karl fischer. As described below, this method can be used in both volumetric and coulometric. Pyridinefree karl fischer reagents home itw reagents. Scope of applications for karl fischer method technical. As shown in the following formula, karl fischer reagents react selectively to water in.